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I thought this post would be a nice follow-up to Silke's recent post on care packages. I've been putting together a package myself, to send to a best friend and her family who moved far far away a year ago.  Taking inspiration from Silke's advent ,  I'm sending lots of small gifts to be unwrapped one per day just for fun... I've been gathering my offerings for quite a while (this was originally conceived as a christmas package, yikes) so I thought I'd share some of online sources I've made use of - some of which are new to me. Pictures of the package to come in a future post... and Hope, if you're reading this, stop.
The plate above was found on etsy, made by the ceramicist , whose work is really nice. is a really sweet online store selling a combination of handmade and vintage products. I love their selection. is an old favorite of many here at our offices and has so many beautiful and charming things. is a great shop with such an inspiring approach in every way, definitely have a look if you haven't already. I love these paper balloons from And though I think we've posted about this here in NYC, its worth doing so again, because what's better than a great candy store! And I recently purchased no less than five copies of to give as gifts to the little people in my life- it was my absolute favorite growing up and has been out of print for a long time. Anyway, we're wondering what your favorite sources are!
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A few of my favorite sites for gifts ...
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“We’re talking about blood flow in the male penile shaft,” explains urologist Ajay Nehra, MD, professor of urology at the Mayo Clinic in Rochester, Minn. Arteries in both the heart and the penis are lined with endothelium, says Dr. Nehra. When the endothelium in these blood vessels doesn’t respond well to the release of nitric oxide (a key part of the chain reaction that allows blood to flow as needed), then blood doesn’t flow into organs, including the penis.
In one Hong Kong-based study involving 2,306 men with type-2 diabetes, slightly more than one fourth of the subjects had erectile dysfunction at the start of the study, and none of the participants had any signs or history of heart disease, stroke or vascular disease. After four years, 123 of these men either experienced a heart attack, died from heart disease, developed chest pain caused by clogged arteries, or needed bypass surgery or a catheter procedure to restore blood flow to the heart. Men who had erectile dysfunction at the beginning of the study were much more likely to experience one of these coronary heart disease (CHD) events. A statistical analysis revealed that out of every 1,000 diabetic men with erectile dysfunction, 19.7 could be expected to experience a CHD event each year, as compared to only 9.5 of 1,000 diabetic men without erectile dysfunction. After a complete analysis of many other factors, the study concluded that erectile dysfunction is an early warning sign for heart disease and that it indicated a 58% increase in the risk for CHD.
The American Academy of Family Physicians says the condition doesn't have to be a natural part of getting older. ED often is attributed to physical or psychological causes. Physical reasons may include:
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Because there is no conclusive evidence about the effectiveness of hormonal blood tests or treatment in patients with low testosterone levels, the ACP doesn't recommend for or against routine use of the tests in ED patients. The college says doctors should make decisions to measure hormone levels based on an individual patient's clinical symptoms (decreased libido, premature ejaculation, fatigue, etc.) and physical signs (such as testicular or muscle atrophy) that suggest hormone problems.
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Drink 50% of your body weight in ounces of water daily (e.g., if you weigh 150 lbs, drink 75 oz of water daily).
In their experiments, the researchers used mice bred to mimic Duchenne muscular dystrophy. Then the scientists gave the rodents doses of Viagra comparable to those taken by men for erectile dysfunction.
Quitting smoking, exercising regularly, losing excess weight, curtailing excessive alcohol consumption, controlling hypertension, and optimizing blood glucose levels in patients with diabetes are not only important for maintaining good health but also may improve erectile function. Some studies suggest that men who have made lifestyle improvements experience increased rates of success with oral medications.
These drugs work by preventing the breakdown of PDE5, which is an enzyme in penile smooth muscle which leads to better function of penile erectile tissue. The PDE5 inhibitors, although not initiating an erection, enhance erections to any given sexual stimulus.
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To exert a measurable antitumor effect, tumor-specific T cells must be present in sufficient numbers and capable of trafficking to their targets. A direct correlation exists between the number of tumor-infiltrating lymphocytes (TILs) and a favorable clinical outcome, as demonstrated in patients with metastatic ovarian cancer (20). Furthermore, the functional status of TILs has been correlated with a favorable prognosis in various human malignancies (20–24). Because PDE5 inhibition augments antitumor immunity, we asked whether sildenafil treatment altered both the number and activation state of TILs. Histological examination of CT26WT tumors revealed a greater intratumoral cellular infiltrate in the sildenafil-treated mice compared with the untreated controls (Fig. 4 A). To better evaluate these differences, C26GM-bearing mice received either tumor-primed or no T cells followed by sildenafil treatment or no additional therapy. The tumors were excised 9 d later, and single cell suspensions were obtained. The T cell infiltrate was analyzed by flow cytometry for CD4+ and CD8+ T cells. This approach enabled us to accurately examine the entire tumor mass and reliably quantify the infiltrating lymphocytic population. Although no increase in CD4+ T cells was observed with PDE5 inhibition (Fig. 4 B, inset), sildenafil treatment greatly increased CD8+ intratumoral infiltration with up-regulation of the activation markers CD69 and CD25 (Fig. 4 C). There were no differences in activation markers between the sildenafil-treated group and sildenafil + ACT, whereas a significant increase in intratumoral T cells were observed in the sildenafil + ACT–treated group compared with sildenafil alone (Fig. 4 B and Fig. S4, available at http://www.jem.org/cgi/content/full/jem.20061104/DC1).
Currently, only commercially available in Asia, Befar® has shown a clinical efficacy of up to 83% in patients with varying degrees of ED. (6) The cream has a onset action of 10-15 minutes and can last 4 hours, and is nearly as effective as the injectable alprostadil. (3, 19)
Therefore, men who produce too little cyclic GMP and men who produce too much PDE5 have problems obtaining and maintaining an erection.
Natural treatment can support erectile function by improving overall health. Erectile dysfunction due to vascular disease may readily respond to nutritional changes and herbal support.
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From: |
A few of my favorite sites for gifts ...
Imagine Childhood
Mommy Tags
Fired and Fused
From: |
Exactly, what could be better than a great candy store!!