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The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Navy Medical Department or the Naval Service at large.
The medication, in addition to its use as a popular treatment for impotence, has already been approved by the U.S. Food and Drug Administration for the treatment of the chronic version of such blood pressure spikes, known as pulmonary arterial hypertension (PAH). The drug has been marketed specifically for this purpose under the trade name Revatio. Another drug -- bosentan -- is also approved for similar purposes.
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A small percentage of men undergo vascular reconstructive surgery to improve blood flow to the penis. Revascularization involves bypassing blocked veins or arteries by transferring a vein from the leg and attaching it so that it creates a path to the penis that bypasses the area of blockage. Young men with only local arterial blockage are the best candidates for this procedure. It may restore function in 50% to 75% of men.
Consider this: Thirty to 50 percent of men with diabetes suffer from erectile dysfunction. Men in their 40s who have erectile dysfunction (ED) are twice as likely to develop cardiovascular disease compared to men without ED. These are just a few examples of how your sexual health relates to overall health.
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Possible blindness due to nonarteritic anterior ischemic optic neuropathy and cilioretinal artery occlusion caused by PDE-5 inhibitors has been a concern. This is an extremely rare event, with only a handful of reported cases from the tens of millions of patients using PDE-5 inhibitor medications. This risk may be increased if the PDE-5 medication is misused or overdosed.
The present findings highlight the significance of partnered relationships and interpersonal factors in the management of erectile dysfunction, and empirically challenge a number of widely held stereotypes concerning men, masculinity, sex, and quality of life. Sand MS, Fisher W, Rosen R, Heiman J, and Eardley I. Erectile dysfunction and constructs of masculinity and quality of life in the multinational Men's Attitudes to Life Events and Sexuality (MALES) study. J Sex Med 2008;5:583-594.
Talking to Your Doctor About Erectile Dysfunction and Your Heart
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Because as many as 25 percent of cases of erectile dysfunction are due to medication side effects,4 the patient's drug therapy should be reviewed. Common pharmacologic causes of this disorder include antihypertensive drugs, most notably the centrally acting agents, beta blockers and diuretics. Antipsychotic and antidepressant drugs are also frequently implicated. Other drugs that can cause erectile dysfunction include spironolactone (Aldactone), cimetidine (Tagamet) and finasteride (Proscar).5,7 Excessive alcohol intake, heroin use and cigarette smoking are also known causes (Table 2).4,7,8
2 Department of OtolaryngologyHead and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287
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Erectile dysfunction is defined as the persistent inability to achieve or maintain penile erection sufficient for sexual intercourse. In the past, patients have underreported this problem because of embarrassment and the belief that little could be done to alleviate it. The availability and marketing of new therapies for erectile dysfunction have greatly increased public awareness of this problem.
Liver and kidney function tests: These blood tests may indicate whether ED may be due to your kidneys or liver functioning improperly.
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the erection or to maintain the erection for the plenty quantity of time during the sexual intercourse. Individuals under the extreme stress are found to build up erectile dysfunction in their life at any point whether temporarily of permanently. Excessive stress is found to reduce the libido in men. Individuals suffering with excessive stress are found to lack the desire for sex.
Erection begins with sexual stimulation. Sexual stimulation can be tactile (for example, by touching the penis), or mental (for example, by having sexual fantasies). Sexual stimulation generates electrical impulses along the nerves going to the penis and causes the nerves to release nitric oxide, which in turn increases the production of cyclic GMP (cGMP) in the smooth muscle cells of the corpora cavernosa. The cGMP causes the smooth muscles of the corpora cavernosa to relax, and allow rapid blood flow into the penis. The in-coming blood fills the corpora cavernosa, making the penis expand.
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The dual specificity cGMP-binding PDE. The four PDE11A variants differ largely in how many and how complete their GAF domains are. The significance of the PDE11 phosphorylation sites is unknown.
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Failure to achieve an erection less than 20% of the time is not unusual and treatment is rarely needed. Failure to achieve an erection more than 50% of the time, however, generally indicates there is a problem requiring treatment.
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